By Emilio Bombardieri, John Buscombe, Giovanni Lucignani, Otmar Schober
The diagnostic and healing achievements in radiopharmaceuticals and nuclear medication instrumentation ? puppy, SPECT, MR, CT and their hypbrids PET-CT and SPECT-CT
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This richly illustrated consultant serves as an creation to scientific terminology. It offers broad assurance of these phrases in relation to common constitution and serve as, problems, prognosis and remedy. a number of illustrations through the booklet -- such a lot in fabulous four-color -- improve informative assurance of standard anatomy, body structure and scientific fabric.
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Extra resources for Advances in Nuclear Oncology:: Diagnosis and Therapy
33. 34. 35. 36. 37. 38. 39. 40. 21 image analysis: associations with other prognostic factors and survival. Br J Cancer 1995; 71: 146–9. Katzenellenbogen JA, Welch MJ, Dehdashti F. The development of estrogen and progestin radiopharmaceuticals for imaging breast cancer. Anticancer Res 1997; 17: 1573–6. Dehdashti F, Picus J, Michalski JM et al. Positron tomographic assessment of androgen receptors in prostatic carcinoma. Eur J Nucl Med Mol Imaging 2005; 32: 344–50. Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S.
High-throughput anaylsis tools in genomics and proteomics help to identify new target molecules which are specifically regulated (up- and/or downregulation) in cancer. The term functional genomics refers to the systematic generation and analysis of information on what specific genes do. Moreover, the genome-wide analysis of gene expression (analysis of the transcriptome), the analysis of protein expression levels (proteomics), and their phenotypic effects are fundamental research advances which will help to discover ever new relevant targets for oncology in general, and imaging in oncological disorders specifically.
18 The αvβ3 integrin is one prominent example of an adhesion molecule that can be targeted for both therapeutic and diagnostic purposes. Finally, enzymes degrading the extracellular matrix are an integral part of tumor angiogenesis, including matrix metalloproteinases, cathepsins, or hyaluronidase. 19–23 For direct imaging of angiogenesis related molecules, various endothelial targets can be successfully visualized, including VEGF and the αvβ3 integrin (see above). 24,25 E-selectin is another potential angiogensis-related target that can be imaged by appropriate affinity ligands.